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What pressing harder does is push more serum through the bore, which is desirable up to a point, and bruise the tissue, which is not
Patients who cannot be screened, or who screen out, are redirected to topical hyperpigmentation protocols
Others prefer every-other-day or three-times-weekly dosing to prevent receptor adaptation
Sometimes our bodies need a bit more of this vitamin, especially if we don't get enough from our food
Its often taken by placing the recommended dosage under the tongue and holding it there for a brief period before swallowing to enhance absorption
This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels
